Nature, Published online: 25 February 2026; doi:10.1038/s41586-026-10150-1
Photograph: Julian Chokkattu
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Abstract:Package managers are legion. Every programming language and operating system has its own solution, each with subtly different semantics for dependency resolution. This fragmentation prevents multilingual projects from expressing precise dependencies across language ecosystems; it leaves external system and hardware dependencies implicit and unversioned; it obscures security vulnerabilities that lie in the full dependency graph. We present the \textit{Package Calculus}, a formalism for dependency resolution that unifies the core semantics of diverse package managers. Through a series of formal reductions, we show how this core is expressive enough to model the diversity that real-world package managers employ in their dependency expression languages. By using the Package Calculus as the intermediate representation of dependencies, we enable translation between distinct package managers and resolution across ecosystems.
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Ian Sample is joined by co-host Madeleine Finlay to find out where the science stands. They also hear from Katherine Tucker, the founder of the Center for Population Health at the University of Massachusetts Lowell. She explains what magnesium is doing in our bodies and the best approach we can take to ensure we are getting enough
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